U of M
Department of


Specialized Program in Research Excellence (SPORE)

The continued hypothesis of this application is that a Specialized Program of Research Excellence (SPORE) in Prostate Cancer at the University of Michigan Comprehensive Cancer Center will reduce the morbidity and mortality of prostate cancer.  We support an interactive group of established and new investigators in a translational research program directed at understanding the biology of prostate cancer as well as developing new tools for the diagnosis, prevention, and treatment of prostate cancer.  Specifically, this SPORE consists of nine multidisciplinary research projects that place special emphasis on:

  • (A) Molecular and Clinical Epidemiology:  Implications for diagnosis, prognosis, and screening with projects that include:

  • Project 1.  Gain of 8q as a Prognostic Factor for Prostate Cancer  (J. Macoska, T. Glover, J. Montie);

  • Project 2.  Epidemiology of Prostate Cancer in African Americans  (J. Montie, D. Schottenfeld, K. Cooney, K. Alcser);

  • Project 3.  Hereditary Prostate Cancer in African American Families  (K. Cooney, J. Montie, D. Schottenfeld);

  • Career Development Project 1.  Cloning and Characterization of a Gene Associated with metastatic Prostate Cancer  (E. Schwab, Career Development) and

  • (B) Novel Therapeutics: Implications for Prevention and Treatment with projects that include

    • Project 4.   Rb as a Regulator of Prostate Tumorigenesis” (M. Day, B. Redman;

    • Project 5.  Inhibition of Human Prostate Cancer Metastasis (K. Pienta, A. Raz, H. Sandler);

    • Project 6.  Vaccinia PSA for Androgen-Modulated, Post-Surgical Recurrence of Prostate Cancer” (M. Sanda, D. Smith);

    • Career Development Project 2.  PHSCN and Related Peptides: Novel Anti-Invasive and Anti-Metastatic Therapeutic Agents (D. Livant);

    • Career Development Project 3.  The Effect of Butyrate on Apoptosis Induced by Radiation, Hormone-Withdrawal, and Chemotherapy in Human Prostate Cancer Cells  (M. Ljungman).

In addition to the main theses, the SPORE has placed special emphasis on the areas of Prostate cancer in African American men (Projects 2 and 3) and Prostate cancer metastasis (Project 5, CD1, CD2) .

The research projects are supported by three cores:

  • Core1.  Administration (K. Pienta)

  • Core 2.  Tissue  and Animal Models (K. Wojno, M. Sanda, K. Pienta)

  •  Core 3.  Biostatistics (D. Normolle).

This SPORE application continues to place emphasis on developmental and pilot projects as well as career development.  The development program includes a rigorous scientific review process and the pairing of scientists in developmental proposals with a basic science and clinical resource mentors.  The SPORE infrastructure has been fully integrated into the Cancer Center and a strong institutional commitment remains in place.